A Jack Russell Terrier named Max lives with his proprietor Katie in a Manhattan condo. While she is grinding away amid the day, he hangs out with different pets in the building: dark-striped feline Chloe, pug Mel, dachshund Buddy, and budgerigar Sweetpea. One day, Katie embraces Duke, a huge mutt from the pound, leaving Max envious in view of her separated concentrate on Duke. Incensed by Max's state of mind towards him, Duke tries to surrender Max in a back road, yet they are both assaulted by felines drove by Sphynx feline Ozone. They expel both pooches' collars and abandon them to be gotten by Animal Control. Duke fears that he will be put down in the event that he backpedals to the pound.

They are saved by a white rabbit named Snowball, the pioneer of 'The Flushed Pets' – a group of sewer-abiding creatures who detest people on the grounds that their proprietors abused them. After Max and Duke put on a show to disdain people as much as they do by saying they executed their proprietors, the Flushed Pets welcome them to join. Before they can demonstrate their faithfulness by permitting a snake to chomp them, Snowball gains from the felines that Max and Duke are trained. The two canines get away from the sewers and board a ship to Brooklyn, coincidentally slaughtering the snake simultaneously; Snowball pledges to execute them and leads the Flushed Pets after them.

Gidget, a white Pomeranian with a frantic pulverize on Max, finds he is missing and enlists a red-followed sell named Tiberius to discover him. Subsequent to investigating the city for Max, Tiberius returns conveying Ozone, whom Gidget constrains into enlightening what he knows regarding the puppies. Gidget and Tiberius then enroll Mel, Buddy, Chloe, guinea pig Norman, Sweetpea, and Pops, an old basset dog to start seeking Manhattan. The gathering experiences Snowball, who pledges to murder them also, and Norman is caught as whatever is left of Gidget's group escapes.

In Brooklyn, Max and Duke attack a hotdog manufacturing plant for nourishment. Duke enlightens Max concerning his past proprietor, Fred, an elderly man who embraced him as a puppy and cherished investing energy with him. One day, Duke got lost while pursuing a butterfly and was gotten by Animal Control, yet Fred never came to claim him. Max persuades him to visit Fred's home in an adjacent neighborhood, sure Fred will even now adore him and take him back. When they arrive, however, they gain from an occupant feline that Fred passed on. Crushed, Duke blames Max for endeavoring to dispose of him and barks at the new property holders who had recently come back to the house, who call Animal Control. The handlers get Max, however Duke meddles sufficiently long for Max to escape and winds up being caught.

While attempting to save Duke as he takes after the Animal Control van, Max is assaulted by Snowball who tries to murder him. Be that as it may, when his group is caught, Snowball understands that he and Max must cooperate to save them. They drive a city transport into the van on the Brooklyn Bridge, halting activity. The Flushed Pets circle Max, ignorant of his organization with Snowball, yet Gidget and her group spare him. At the point when Gidget is utilizing her kung-fu battling aptitudes, Max begins to become hopelessly enamored with her. The van rolls away; the Flushed Pets escape, however the van falls into the East River with Duke inside. Max can't get the keys to Duke's enclosure, so Snowball bounced into the waterway to recover them, permitting Max and Duke to get away from the sinking van. Once out of the stream, Snowball acknowledges how great being courageous feels.

The whole gathering comes back to the condo hinder by pig-driven taxi. Max communicates his adoration for Gidget, who gives back his fondness. Snowball and the Flushed Pets then concoct another arrangement to demolish all people, however Snowball is abruptly embraced by a young lady. At to begin with, Snowball opposes, however gives in and gives himself a chance to wind up plainly a trained pet. The staying Flushed Pets come back to the sewers, the trained pets come back to their homes and grasp their proprietors, and Max and Duke at long last rejoin with Katie, starting a genuine fellowship.